The initial co-signatories of the Global NCD Compact 2020–2030 are the World Health Organization, the Government of Norway, and the Government of Ghana. Further Member States expected to support as signatories later in 2022. The Global NCD Compact focuses on five areas of commitment: 

• saving, by 2030, the lives of 50 million people from dying prematurely of NCDs by implementing the most cost-effective measures to prevent and control NCDs; 
• protecting 1.7 billion people living with NCDs by ensuring that they have access to the medicines and care they need during humanitarian emergencies; 
• integrating NCDs within primary health care and universal health coverage; 
• comprehensive NCD surveillance and monitoring; and 
• meaningfully engaging 1.7 billion people living with NCDs and mental health conditions in policy-making and programming. 

Looking ahead to 2030, Heads of State and Government, and those signing up to the NCD Compact will underscore their commitment and take the following actions, amongst others, aligned with the Implementation Roadmap:​

1. Engage with UN agencies, academia, nongovernmental organizations, philanthropies, the private sector, civil society, and people with lived experiences of NCDs and mental health conditions to make progress and tailor NCD interventions to national health system contexts and population needs and raise the priority and fulfil the commitments made for the prevention and control of NCDs. This will include new ways to strengthen collaborations in resourcing, knowledge-sharing and technical assistance for bolder national NCD responses. ​
2. Accelerate country action, based on the NCD Implementation Roadmap 2023–2030, by implementing the best-buys and WHO NCDs technical packages including: PEN, HEARTS, MPOWER, SAFER, SHAKE and ACTIVE and also including reorientation of PHC and strengthening of health systems; acceleration of socioeconomic development, promoting health security, and consolidating global health sustainability.​
3. Invest adequate, predictable, and sustained resources for the prevention and control of NCDs, through domestic, bilateral, and multilateral channels including through the Multidonor Trust fund on NCDs and develop global health and development strategies for the prevention and control of NCDs in LMIC as appropriate. ​
4. Align the NCD agenda by integrating it in the preparedness an response to humanitarian emergencies and environmental changes; reproductive, maternal, newborn and child health; HIV and TB; and reorient PHC and build resilient health systems, services and infrastructure to prevent and treat people living with NCDs and maximize health outcomes.​
5. Account to prioritize interventions, assess implementation and learn from the impact of NCD prevention and control through strengthened surveillance and monitoring to obtain reliable and timely data at national and subnational levels on NCD risk factors, diseases, mortality, and systems. Use NCD-related indicators in health systems performance and access to health care metrics for data driven action to scale up and deliver the most feasible and impactful interventions.​