Tools and methods
To develop internationally harmonized tools and methods to support country vaccine safety activities
It is important that vaccine safety monitoring methods, investigation procedures and public health responses are harmonized. Only then can safety data from one situation be used to help prevent problems in another.
Tools and methods for vaccine safety are rapidly evolving thanks to modern information technologies. WHO works with leading global experts with a range of expertise and from different backgrounds to develop standard procedures and methods.
International standardization of data records will facilitate the exchange of information and the global identification of vaccine safety signals.
Resources
WHO guidance for vaccine safety presentations to GACVS
Causality assessment of an adverse event following immunization - User manual for the revised WHO AEFI causality assessment classification
Information sheets on observed rates of vaccine reactions
Safety of mass immunization campaigns - 2002
Safety of immunization during pregnancy - a review of the evidence by the GACVS
- Immunization stress-related responses (ISRR) – a manual
- Immunization stress-related responses (ISRR) – a synopsis
- Safety of mass immunization campaigns - 2002 (pdf, 378kb)
- Aide-memoire to ensure the efficiency and safety of mass immunization campaigns with injectable vaccines - 2004
- Safety of immunization during pregnancy - a review of the evidence
- Global manual on surveillance of adverse events following immunization
- Serious adverse events associated with HPV vaccination, pdf, 2.48Mb (external publication)
- Update of a systematic review and meta-analysis of the safety, effectiveness and efficacy of childhood schedules using rotavirus vaccines
- Identifying & responding to serious Adverse Events Following Immunization, following use of smallpox vaccine during a Public Health Emergency - A guidance document for smallpox vaccine safety surveillance