Strategic Advisory Group of Experts on Immunization (SAGE) - April 2015

Background documents

Meeting of the Strategic Advisory Group of Experts on immunization, October 2014 – conclusions and recommendations

SAGE tracking record of recommendations and action points

Framework of engagement with non-State actors - Draft decision proposed by Argentina

Framework of engagement with non-State actors: Report by the Secretariat

Framework of engagement with non-State actors: information on regional committee debate

Ebola: ending the current outbreak, strengthening global preparedness and ensuring WHO?s capacity to prepare for and respond to future large-scale outbreaks and emergencies with health consequences, EBSS3.R1

Global vaccine action plan, Report by the Secretariat, EB136/25

WHO 136th Executive Board, Global Vaccine Action Plan, Document 136/25, agenda item 9.3, Geneva, 26th January 2015, summary of the session

WHO 136th Executive Board, Global Vaccine Action Plan, item 9.3, Geneva, 26th January 2015, countries and NGOs interventions, informal summary records

Regional Committee for Africa: resolution - regional strategic plan for immunization 2014–2020 (Document AFR/RC64/5)

Regional Committee for Africa: regional strategic plan for immunization 2014–2020. Report of the Secretariat

TFI Members Meeting, Brazzaville, Congo, 4-5 December 2014 - Draft Recommendations

Twenty-eighth meeting of national managers of the Expanded Programme on Immunization, Amman, Jordan, 16–19 November 2014

Summary report on the Fifteenth intercountry meeting on measles/rubella control and elimination, Amman, Jordan, 22–25 November 2014

Meeting of chairpersons of the national immunization technical advisory group (NITAGs) in countries of the eastern mediterranean region

ETAGE report, January 2015

Presentations

Global report including key updates and challenges from regions - J.M. Okwo-Bele

Background documents

Executive summary of the GAVI December 2014 Board Meeting, Geneva, Switzerland

Presentations

Report from the GAVI Alliance - S. Berkley

Background documents

Global Advisory Committee on Vaccine Safety, 3-4 December 2014

Presentations

Report of the Global Advisory Committee on Vaccine Safety (GACVS) - M. Wharton

Product Development for Vaccines Advisory Committee (PDVAC) criteria used for prioritizing vaccines for the work of the Initiative for Vaccine Research - D. Kaslow

Background documents

SAGE Polio Working Group, Thursday, 19 February 2015, Conference Call Notes

SAGE Polio Working Group, Thursday, 13 March 2015, Conference Call Notes

Persistent circulating vaccine-derived poliovirus type 2 (cVDPV2) - current status in preparation of the tOPV to bOPV switch

Type 2 OPV withdrawal: update on readiness and preparations for the switch

Presentations

Objective of the session; overview of Global Polio Eradication Initiative - H. Jafari

Epidemiology of cVDPVs and updated SIA calendar - A. Quddus

Report from SAGE WG (1. Contingency plan in case of prolonged cVDPV circulation and 2. WHO verification process of essential facilities) - P. Figueroa

Updates on preparation for OPV2 withdrawal (e.g. IPV introduction, operationalizing OPV2 withdrawal, bOPV licensures and containment) - M. Zaffran

Background documents

Executive Summary for April 2015 SAGE Session on Administration of Multiple Injectable Vaccines at a Single Visit

Dudley, L. et al. The acceptability of three vaccine injections given to infants during clinic visits in South Africa. A Report to the WHO Department of Immunization, Vaccines and Biologicals, November 2014

Summary: 2015 Tanzania Multiple Injections Study: Provider and Caregiver Survey In Preparation for IPV Introduction

Experiences with provider and parental attitudes and practices regarding the administration of multiple injections during infant vaccination visits: Lessons for vaccine introduction _Aaron S. Wallace et al. Vaccine, 2014

Summary of evidence on the administration of multiple injectable vaccines in infants during a single visit: safety, immunogenicity, and vaccine administration practices. Prepared for the April 2015 SAGE Meeting

Presentations

Introduction - K. O'Brien

Acceptability of 3 vaccine injections given to infants in South Africa - C. Wiysonge

Summary of evidence on the administration of multiple injectable vaccines in infants: attitudes of healthcare providers and caregivers - A. Wallace

Summary of evidence on immune system effects, safety, administration practices and programmatic issues related to administration of multiple injectable vaccines during a single visit - S. Dolan

Summary of the findings and proposed recommendations - K. O'Brien

Background documents

Report to SAGE on reducing pain and distress at the time of vaccination, 24 march 2015

The following documents:

- Methodology for HELPinKids&Adults knowledge synthesis of vaccination pain, A Taddio

- HELPinKids&Adults 2.0 (expanded and updated): Clinical practice guideline for reducing pain and fear from vaccine injections in children and adults

- HELPinKids&Adults, Grade Revman

will be accessible once they are formally published in the CMAJ

Gidudu JF et al. Immunization site pain: Case definition and guidelines for collection, analysis, and presentation of immunization safety data. Vaccine 30 (2012) 4558– 4577

Presentations

Introduction (importance, landscape analysis, objectives, and methods) - N. Turner

Impact of pain and distress at the time of vaccination - N. MacDonald

Systematic review of effectiveness and safety of interventions aimed at reducing pain and distress at the time of vaccination - A. Taddio

Proposed recommendations for reducing pain and distress at the time of vaccination - N. Turner

Background documents

Sustainable Access to Vaccines in Middle-Income Countries (MICs): A shared partner strategy report of the WHO-Convened MIC task force, March 2015

Presentations

Introduction of the session - Y. Al-Mazrou

The ‘Middle Income Countries issue’: reframing the problem - J. Andrus

A shared MICs strategy - T. Cernuschi and G. Gandhi

Background documents

Interim report to WHO initiative for vaccine research, WHO taskforce to evaluate influenza data to inform vaccine impact and economic modelling, 24 March 2015

2015 maternal immunization stakeholder convening path to impact, Bill & Melinda Gates Foundation, 29-30 January 2015, Berlin, Germany

Presentations

Introduction - C.A. Siegrist

WHO’s agenda on Maternal Immunization - J. Hombach

Review of influenza disease risk and incidence relevant to maternal immunization: Report from WHO IVIR-AC influenza working group - B. Gessner

Summary of the March maternal influenza meeting on new data and implementation - K. O'Brien

Implementation research gaps for furthering maternal immunization - J. Ortiz

Background documents

Draft framework for formulating recommendations for the deployment of Ebola vaccines. SAGE Working Group on Ebola Vaccines and Vaccination

Presentations

Introduction - O. Tomori

Update on the epidemiology of EVD, C. Dye. This presentation cannot be made publicly available in it's entirety for confidentiality reasons. A modified version is forthcoming.

Status of phase 1 and 2 trials and summary of preliminary results from phase 1 trials - V. Sathiyamoorthy. This version has been modified form the original shown during the meeting for reasons of confidentiality.

Update on phase 3 trials (design and status) - A.M. Henao Restrepo

Preparations for vaccine deployment - M.P. Preziosi

Framework for recommendations for deployment of vaccines - H. Rees

Background documents

Report from the SAGE Working Group on pertussis vaccines, 26-27 August 2014,meeting, Geneva, Switzerland

Whole Cell Pertussis Vaccines: Summary of evidence relevant to schedules.

The Immunological Basis for Immunization Series Module 2: Diphtheria, Update 2009

The Immunological Basis for Immunization Series Module 3: tetanus, Update 2006

Part 1: Diptheria and tetanus vaccines comparative efficacy/effectiveness of schedules in infant immunisation against pertussis, diphtheria and tetanus: Systematic review and meta-analysis

Part 2: Whole-cell pertussis vaccine comparative efficacy/effectiveness of schedules in infant immunisation against pertussis, diphtheria and tetanus: Systematic review and meta-analysis

Review on aP schedules and absolute effect - Figures and Tables Version August 19, 2014

Systematic Review Report topic: Safety from randomized controlled trials and observational studies of pertussis vaccines. Prepared for the Initiative for Vaccine Research, World Health Organization. Hanna Bergman & Karla Soares-Weiser, Enhance Reviews Ltd, August 10, 2014

Presentations

Introduction: Background and framing of the questions for SAGE - C.A. Siegrist

Evidence in support/against various primary DTP vaccination schedules - E. Miller

Modeling of impact of different DTP schedules - A. Clark

Summary and recommendations - C.A. Siegrist