Strategic Advisory Group of Experts on Immunization (SAGE) - October 2017

17 – 19 October 2017

The SAGE meeting of 17-19 October 2017 was held in the Executive Board (EB) room at WHO HQ in Geneva. Available on this site you will find meeting information, background reading materials and presentations made at the meeting. The conclusions and recommendations of SAGE meeting are published in the WHO Weekly Epidemiological Record in English and French within two months of each SAGE meeting.

Meeting materials

 

Related

Background documents and Presentations

SAGE Yellow Book for October 2017

 

Session: Report from IVB director

Background documents

Meeting of the Strategic Advisory Group of Experts on immunization, April 2017 – conclusions and recommendations

SAGE tracking record of recommendations and action points

Report of the AFRO Regional Immunization Technical Advisory Group Meeting, Brazzaville, Congo, 6-7 June 2017

Technical Advisory Group on Vaccine-preventable Diseases (TAG), XXIV Meeting, Panama City, Panama, 12-14 July 2017

29th Pan American Sanitary Conference: 69th Session of the Regional Committee of WHO for the Americas, Washington, D.C., USA, 25-29 September 2017

Meeting Report: 26th Meeting Of The Technical Advisory Group On Immunization And Vaccine-Preventable Diseases in the Western Pacific Region, Manila, Philippines, 13–16 June 2017

The 5th Meeting of the Combined Sub-regional Committees for the Certification of Poliomyelitis Eradication and Verification of Measles Elimination in Pacific Island Countries and Areas (SRCC/SRVC), 9-11 May 2017

Consultation on Regional Measles and Rubella Elimination in the Western Pacific, Manila, Philippines, 19-21 April 2017

Eighth meeting of SEAR Immunization Technical Advisory Group (ITAG) New Delhi, India, 12-16 June 2017

Presentations

Global report including key updates and challenges from regions - J.M. Okwo-Bele

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Session: Report from GAVI, the Vaccine Alliance

Session: Report from other advisory committees on immunization

Session: Typhoid vaccines

Background documents

Background Paper to SAGE on Typhoid Vaccine Policy Recommendations

Cost-effectiveness analysis of typhoid conjugate vaccines in five endemic low- and middle-income settings, Vaccine publication, June 2017

Typhoid Vaccine Acceleration Consortium (TyVAC) – Executive Summary

Summary of Findings: Typhoid Vi-polysaccharide vaccine versus placebo or control vaccine in children and adults

Summary of Findings: Typhoid Ty21a vaccine versus placebo or control vaccine in children and adults

Typhoid vaccines: Evidence to recommendation Table

Presentations

Introduction - I. Jani

Overview of the epidemiology and global disease burden of typhoid fever - J. Crump

Current control strategies, antimicrobial resistance of S. Typhi and implications for typhoid control - Z. Bhutta

Conclusions and proposed recommendations of the SAGE Working Group on Typhoid Vaccines - I. Jani

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Session: Global polio eradication initiative

Background documents

Fourteenth Meeting of the SAGE Polio Working Group (WG) WHO, Geneva, February 9-10, 2017

Concept Note: Grading the risk of a serotype 2 vaccine-derived polio virus (VDPV2) outbreak in Tier 3 and 4 countries

Cessation Risk Assessment Meeting, June 13-14, 2017: Summary

Draft Post-Certification Strategic Plan

Ousmane DM et al. Virologic Monitoring of Poliovirus Type 2 after Oral Poliovirus Vaccine Type 2 Withdrawal in April 2016- Worldwide, 2016–2017, Morbidity and Mortality Weekly Report 2017 

Hampton LM et al. Cessation of Trivalent Oral Poliovirus Vaccine and Introduction of Inactivated Poliovirus Vaccine-Worldwide, 2016, Morbidity and Mortality Weekly Report 2016

Okayasu H et al. Intradermal Administration of Fractional Doses of Inactivated Poliovirus Vaccine: A Dose-Sparing Option for Polio Immunization, The Journal of Infectious Diseases 2017

Anand A et al. Immunogenicity to poliovirus type 2 following two doses of fractional intradermal inactivated poliovirus vaccine: A novel dose sparing immunization schedule, Vaccine 2017

Polio Endgame & Legacy-Implementation, Best Practices, and Lessons Learned, The Journal of Infectious Diseases 2017

Presentations

Overview of Global Polio Eradication Initiative - M. Zaffran

Risk assessment and prioritization of Inactivated polio vaccine (IPV) supply and implementation of fractional IPV (fIPV) in the routine immunization - D. Chang Blanc

Post certification strategy (PCS) - B. Burkholder

Report from SAGE Polio Working Group on Polio - Y. AL-Mazrou

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Session: Global Vaccine Action Plan (GVAP): Progress report

Background documents

2017 assessment report of the Global Vaccine Action Plan: strategic advisory group of experts on immunization

Tools for CSO engagement and reporting in support of national immunization plans

Global Vaccine Action Plan. Draft Secretariat Annual Report 2017

Global Vaccine Action Plan. Regional reports on progress towards GVAP‑RVAP goals. Annex to the GVAP Secretariat Annual Report 2017

Global Vaccine Action Plan. Priority Country reports on progress towards GVAP-RVAP goals. Annex to the GVAP Secretariat Annual Report 2017

National Immunization Coverage Scorecards Estimates for 2016

Presentations

Summary of GVAP implementation progress review and recommendations for corrective actions - N. MacDonald

Immunization related Sustainable Development Goals indicator options and proposal retained by the Decade of Vaccines Working Group - N. Arora

Presentation of the proposed process to develop a Global Immunization Strategy 2021-2030 - C. Mantel

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Session: Report of activities from international immunization partners

Session: Rabies vaccines

Background documents

Background paper: Proposed Revision of the Policy on Rabies Vaccines and Rabies Immunoglobolins

Appendix I: Strategic Advisory Group of Experts (SAGE) Working Group on rabies vaccines and rabies immunoglobulins (terms of reference, members, declaration of interest

Appendix II: Evidence profiles Questions 1-14 including GRADE tables and evidence review on potency of rabies vaccine, if fractionated

Appendix III: Evidence to recommendation tables for PICO questions

Presentations

Overview of the global rabies situation - B. Abela-Ridder

Presentation of evidence on vaccination for pre-exposure rabies prophylaxis (PREP) (Question 1,2,3,4) - A. Tarantola

Conclusions and proposed recommendations (Question 1,2,3,4) - K. O'Brien

Presentation of evidence on vaccination for post-exposure rabies prophylaxis (PEP) (Question 5,6,7,8,9) - A. Tarantola

Conclusions and proposed recommendations (Question 5,6,7,8,9) - K. O'Brien

Presentation of evidence on rabies immunoglobulins (RIG) for PEP (Questions 10,11,12,13,14) - A. Tarantola

Conclusions and proposed recommendations (Questions 10,11,12,13,14) - K. O'Brien

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Session: Pneumococcal conjugate vaccines (PCV)

Session: Measles and rubella elimination

Background documents

Critical immunity thresholds paper

Measles in infants less than 6 months and effectiveness and safety of vaccination

Should an additional dose of MCV be recommended for HIV infected adolescents and adults

The Global Vaccine Action Plan (GVAP) Goal 2: Meet Global and Regional Elimination Targets. Achieve Measles Elimination (Indicator G2.2)

Measles vaccines: WHO position paper - April 2017

Rubella vaccines: WHO position paper - July 2011

Systematic literature review and meta-analyses of the benefits and risks of measles vaccination below 6 months of age

Epidemiology of measles in infants younger than 6 months: analysis of surveillance data 2011-2016

Presentations

Introduction - N. Turner

Global update and progress on the implementation of recommendations from the midterm review - A. Dabbagh

Critical immunity threshold for measles elimination - S. Funk

Measles in infants less than 6 months of age and effectiveness and safety of vaccination - N. Crowcroft

Re-vaccination of HIV infected adults - W. Moss

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Session: Bacille Calmette-Guérin (BCG) vaccines

Background documents

Report on BCG vaccine use for protection against mycobacterial infections including tuberculosis, leprosy, and other non-tuberculous mycobacteria (NTM) infections

BCG Evidence to Recommendation Tables 1-5

Roy et al. Mathematical modelling to estimate the impact of age of BCG vaccination on global paediatric TB mortality. Unpublished

Mangtani et al. Protection by BCG vaccine against tuberculosis: a systematic review of randomized controlled trials. Clinical Infectious Diseases, 15 February 2014

Gillini et al. Global practices in regard to implementation of preventive measures for leprosy. PLOS Neglected Tropical Diseases 2017

Presentations

Introduction

Efficacy, effectiveness and duration of protection of BCG vaccination against TB - P. Mangtani

Safety of BCG vaccination and implications for HIV-exposed and infected children - K. Johansen

Use of BCG for the prevention of leprosy - L. Gillini

Conclusions and proposed recommendations - C. Wiysonge

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