Strategic Advisory Group of Experts on Immunization (SAGE) - October 2018

23 – 25 October 2018

The SAGE meeting of 23-25 October 2018 took place at the Centre International de Conference in Geneva. Available on this site you will find meeting information, background reading materials and presentations made at the meeting. The conclusions and recommendations of SAGE meeting are published in the WHO Weekly Epidemiological Record in English and French within two months of each SAGE meeting.

Meeting materials

Related

Background documents and presentations

SAGE Yellow Book for October 2018

 

Session: Report from IVB director

Background documents

Meeting of the Strategic Advisory Group of Experts on immunization, April 2018 – conclusions and recommendations

SAGE tracking record of recommendations and action points

Report of the AFRO Regional Immunization Technical Advisory Group Meeting (RITAG) - 29-30 June 2018, Kigali, Rwanda

Report of the PAHO regional Technical Advisory Group (TAG) on vaccine-preventable diseases - 10 July 2018, Washington D.C., USA

Report of the SEARO regional Immunization Technical Advisory Group (SEAR-ITAG) - 17 - 20 July 2018, New Delhi, India

Report of the WPRO regional Technical Advisory Group on Immunization and Vaccine-preventable Diseases - 19 - 22 June 2018, Manila, Philippines

Presentations

Immunization in a Changing World From April-October 2018: What a difference 6 months makes - M. Friede

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Session: Report from Gavi, the Vaccine Alliance

Background documents

No background documents provided for this session.

Presentations

Report from Gavi, the Vaccine Alliance - S. Berkley

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Session: Report from other advisory committees on immunization

Background documents

Global Advisory Committee on Vaccine Safety (GACVS), 6–7 June 2018

Annotated IVIR-AC Agenda 2018 (draft) - 24 - 26 September 2018

Immunization and Vaccine related Implementation Research Advisory Committee (IVIR-AC) recommendations September 2018

Immunization Practices Advisory Commitee (IPAC) 12th Meeting - 11- 12 July 2018, Geneva, Switzerland

WHO’s 5th Product Development for Vaccines Advisory committee (PDVAC) meeting- 26 - 28 June 2018, Geneva, Switzerland

PDVAC background document: The potential role of the Controlled Human Infection Model (CHIM) in advancing licensure and introduction of next-generation O- antigen-based vaccines against Shigella- Cal MacLennan (BMGF) and Birgitte Giersing (IVR WHO)

PDVAC bacground document: WHO Preferred Product Characteristics for New Tuberculosis Vaccine

Presentations

Report from Global Advisory Committee on Vaccine Safety (GACVS) - R. Pless (Recorded from June 2018 meeting)

Report from the Immunization and Vaccine related Implementation Research (IVIR) Advisory Committee - W. Orenstein

Report from Immunization Practice Advisory Committee (IPAC) - C. Morgan

Report from Product Development for Vaccines Advisory Committee (PDVAC) - D. Kaslow

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Session: Global Vaccine Action Plan (GVAP)

Session: Report of activities from international immunization partners

Session: Polio

Session: Measles and Rubella

Background documents

Executive summary for SAGE session on measles and rubella

Feasibility of Measles and Rubella Eradication - draft outline of report to the World Health Assembly (WHA)

Background Paper on Immunologic Response to Measles-Containing Vaccines (MCVs) and Yellow Fever (YF) vaccines when co-administered

Guidance to Increasing Population Immunity against Measles and Rubella, Global Immunization Division, Center for Global Health US Centers for Disease Control and Prevention

Meeting of the International Task Force for Disease Eradication, 10 November 2015, Atlanta, USA

Proceedings of the Global Technical Consultation to Assess the Feasibility of Measles Eradication

Mutual interference on the immune response to yellow fever vaccine and a combined vaccine against measles, mumps and rubella, Vaccine journal 2011

Safety and immunogenicity of inactivated poliovirus vaccine when given with measles–rubella combined vaccine and yellow fever vaccine and when given via different administration routes: a phase 4, randomised, non-inferiority trial in The Gambia, The Lancet, August 2016

Appendix - Safety and immunogenicity of inactivated poliovirus vaccine when given with measles–rubella combined vaccine and yellow fever vaccine and when given via different administration routes: a phase 4, randomised, non-inferiority trial in The Gambia, The Lancet, August 2016

Chronovac Voyageur: A study of the immune response to yellow fever vaccine among infants previously immunized against measles,Vaccine journal, 2017

Presentations

Session introduction Global update - A. Dabbagh

Feasibility of MR eradication - B. Moss

Co-administration of the YF vaccine with measles containing vaccines - J. Harris

Country classifications and guidance to increasing population immunity - S. Reef

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Session: Human papilloma virus (HPV) vaccines

Background documents

Executive summary for SAGE session on HPV

Background paper for SAGE deliberations - HPV immunization schedules and strategies

Working Group on Human Papillomavirus (HPV) immunization - Report to SAGE

Systematic review of cost-effectiveness studies of human papillomavirus (HPV) vaccination: 9-Valent vaccine, gender-neutral and multiple age cohort vaccination, Vaccine journal, 2018

Experiences of operational costs of HPV vaccine delivery strategies in Gavi-supported demonstration projects, PLOS One journal, October 10 2017

Costs of Introducing and Delivering HPV Vaccines in Low and Lower Middle Income Countries: Inputs for GAVI Policy on Introduction Grant Support to Countries, PLOS One journal, Vol.9, Issue 6, June 2014

Costs of delivering human papillomavirus vaccination to school girls in Mwanza Region, Tanzania, BMC Medicine publication, 2012

A case study using the United Republic of Tanzania: costing nationwide HPV vaccine delivery using the WHO Cervical Cancer Prevention and Control Costing Tool, BMC Medicine publication, 2012

HPV vaccines in females over 25 years

Worldwide burden of cancer attributable to HPV by site, country and HPV type, International Journal of Cancer (IJC), 2017

Global Market Study: HPV - September 2018

Presentations

Session introduction and key questions - R. Aggarwal

Update on HPV vaccine introduction and programmatic perspective - T. Goodman

Overview of evidence regarding HPV immunization on different disease outcomes - A. Pollard

Forecast impact of different immunization strategies and screening scenarios towards cervical cancer elimination - M. Brisson

Conclusions and proposed recommendations by SAGE Working Group - R. Aggarwal

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Session: Ebola

Background documents

Executive summary for SAGE session on Ebola

Update with the development of Ebola vaccines and implications of emerging evidence to inform future policy recommendations

Interim recommendation Ebola vaccines

Presentations

Session introduction and key questions - F. Were

Overview of Ebola epidemiology - D. Heymann

Update on candidate Ebola vaccines: available data on immunogenicity, efficacy and safety, timelines for licensure and Expanded Access/Compassionate Use experience - A.M. Henao Restrepo

Benefits and risk analysis of vaccination of pregnant women with rVSV-ZEBOV as part of Expanded Access/ Compassionate Use during Ebola outbreaks - J. Edmunds and C. Jarvis

Observed and forecasted impact of different Ebola candidate immunization strategies and targeted populations - A. Camacho

Proposed recommendations by SAGE Working Group - H. Rees and F. Were

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Session: Lessons learned from Diphtheria outbreaks - opportunities for early warning and preventive action

Background documents

Executive summary for SAGE session on lessons learned from diphtheria outbreaks

Update on Supply of Diphtheria Antitoxin and the Ad-Hoc Working Group on DAT

WHO position paper on diphtheria (August 2017)

Vaccination In Acute Humanitarian Emergencies: A Framework For Decision Making

Vaccine Decision Information System - Concept note for SAGE, Wilbert van Panhuis, MD PhD

WHO surveillance standards - diphtheria

Ensuring Sustained Protection Against Diphtheria: Replacing TT with Td vaccine, Wilbert van Panhuis, MD PhD

Presentations

Introduction to session - F. Qadri

Case study: Diphtheria Outbreak in Cox Bazaar - S. Bahl

Global Opportunities and Gaps in Preventing Diphtheria Outbreaks - M. Gacic-Dobo

Country level risk assessment: example of possible approaches to guide country level actions - A.M. Henao Restrepo

Vaccine decision information systems - W. van Panhuis

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