Guidelines for HIV post-exposure prophylaxis

Overview

Despite advancements in testing and treatment, over one million people became infected with HIV in 2022. This warrants a need for a revitalized focus on proven HIV prevention interventions such as HIV post-exposure prophylaxis (PEP).

WHO’s updated PEP guidelines prioritize broader access to PEP, including community-based delivery and task sharing to mitigate barriers such as stigma and to ensure timely access post exposure. PEP involves administering antiretroviral (ARV) medication after potential HIV exposure to prevent infection. Timely access to PEP is the most crucial factor in PEP effectiveness. PEP is most effective when initiated as soon as possible, ideally within 24 hours and no later than 72 hours after exposure.

While a PEP regimen of two drugs can be effective, three drugs are preferred. It is recommended that people be given a 28-day prescription for PEP. This guideline includes recommended drug regimens for adults, adolescents and children.