Clinical management and infection prevention and control for mpox: living guideline, May 2025
Overview
This document is for public health specialists, health emergency responders, clinicians, health facility managers, health and care workers and IPC practitioners including but not limited to those working in primary care clinics, sexual health clinics, emergency departments, dental practices, infectious diseases clinics, genitourinary clinics, maternity services, paediatrics, obstetrics and gynaecology and acute care facilities that provide care for patients with suspected or confirmed mpox.
The mpox guideline is available in online interactive format on the Magic platform here.
This living guideline from WHO incorporates new evidence to dynamically update recommendations for clinical management and IPC for mpox infection. The GDG typically evaluates an intervention when WHO judges sufficient evidence is available to make a recommendation. While the GDG takes an individual patient perspective in making recommendations, it also considers resource implications, acceptability, feasibility, equity and human rights. Some IPC interventions are listed as good practice statements and have been formulated according to the principles outlined in the GRADE (Grading of Recommendations Assessment, Development and Evaluation) framework and further described in the Methods section of the document. This updated version of the guideline was developed according to standards and methods for trustworthy guidelines.
