Fractional dose yellow fever vaccine as a dose-sparing option for outbreak response

Overview

Ongoing  YF  outbreaks  are  sharply  increasing  the  demand  for  YF  vaccine,  exhausting  the  global  stockpile and  putting  at  risk  the  immunization  of  endemic populations.   With the  campaigns planned, there  is now shortage  of  vaccine,  which  could  increase  further  if  expansion  of  outbreaks  would  require  additional immunization  campaigns at  large  scale.  Hence,  there  is a need  to  assess  immediate  opportunities  to increase  availability  of vaccine  in  response  to  ongoing  outbreaks that  deplete  available supplies.