INN for fusion protein

Overview

The -fusp naming scheme is not designed to give comprehensive information about the substance in the name, but rather to indicate that it is a fusion protein and its type. It is reasoned that the description at the level of publication will provide more extensive information about the precise content and action of the fusion protein. All components must be endowed with a pharmacological activity. In a bifunctional fusion protein, if one component has a purely stabilizing function (e.g. to increase half-life), no “-fusp” will be assigned. For instance, if the component is a stabilizing Fc fragment, the “ef-” prefix should be used, not -fusp. In a multifunctional fusion protein that has more than one pharmacological action, but also contains a stabilizing Fc fragment, both ef- and -fusp should be used.