New INN monoclonal antibody (mAb) nomenclature scheme (May 2022)

Overview

-tug for “unmodified immunoglobulins”
The suffix -tug is used for monospecific full-length immunoglobulins with unmodified constant regions and identical sets of CDRs that recognize the same epitope.

-bart for “artificial immunoglobulins”
The suffix -bart is used for monospecific full-length immunoglobulins with engineered amino acid changes in the constant regions and identical sets of CDRs that recognize the same epitope.  

-ment for “immunoglobulin fragments”
The suffix -ment is used for monospecific fragments of any kind that do not fall under stem -tug or -bart, containing at least one immunoglobulin variable domain that contributes to binding, and feature a complete, partial or absent constant region (e.g., monospecific immunoglobulin-derived constructs without an Fc domain, scFv-Fc constructs).

-mig for “multi-specific immunoglobulins”
The suffix -mig is used for bispecific and multispecific immunoglobulins, regardless of the format (conventional or engineered), type (full-lenght or fragments) or shape (extensions or not).