Mpox global strategic preparedness and response plan

Overview

The Global Strategic Preparedness and Response Plan (SPRP) for mpox, covering the six-month period from September 2024 to February 2025, provides a framework for public health preparedness and response to the mpox emergency. The SPRP was developed with input from Member State and partners and outlines the urgent actions needed at global, regional, and national levels.

The WHO Director-General determined that the mpox upsurge was a public health emergency of international concern on 14 August 2024, given the detection and rapid spread of a new clade of mpox in eastern Democratic Republic of the Congo, its detection in neighbouring countries that had not previously reported mpox, and the potential for further spread within Africa and beyond.

The SPRP emphasizes surveillance, research, equitable access to medical countermeasures, and community empowerment to respond to this global emergency. The initial six-month operation will focus on controlling acute outbreaks of human-to-human transmission, with an estimated 4,000 cases per week and an estimated budget of US$ 290 million for international support to national mpox responses.

An update to this document was published in April 2025 and is available here.