PDVAC Agenda 2020: Update on development of Enterotoxigenic E.coli (ETEC) vaccines

Overview

2020 WHO Product Development for Vaccines Advisory Committee (PDVAC) Virtual Consultation 4: Update on development of Enterotoxigenic E.coli (ETEC) vaccines: 18 June 2020

CHAIR: David Kaslow

This session seeks to review the status of candidates in development, the tools, assays and models that are available to facilitate that development and the data from the recent ETVAX studies, including the Phase IIb efficacy study in travelers. Of particular interest are the intended ‘next steps’ for the pediatric indication, and whether, or what, facilitation from PDVAC/IVB is needed.

Objectives of the meeting:

• To provide a status update on candidate and funding landscape for ETEC vaccines
• To evaluate the outcomes of the ETVAX efficacy study in adult travellers and plans for the paediatric indication
• To determine if ETEC should remain a “priority” pathogen for PDVAC and if yes, whether there are activities that WHO/PDVAC should engage in going forward?