Zoonotic tuberculosis (TB) is a form of TB in people caused by a subspecies of the Mycobacterium tuberculosis complex that is usually found in animals. Cattle are the most important animal reservoir of TB in relation to zoonotic exposure of humans, but the disease can affect many other species and become established in wildlife reservoirs. It results in important economic losses and trade barriers with a major impact on the livelihoods of poor and marginalized communities.