e-Library of Evidence for Nutrition Actions (eLENA)


An online library of evidence-informed guidelines for nutrition interventions and single point of reference for the latest nutrition guidelines, recommendations and related information.

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Biofortification of staple crops

Intervention | Last updated: 20 June 2023


Fortification is the practice of deliberately increasing the content of an essential micronutrient, i.e. vitamins and minerals (including trace elements) in a food, so as to improve the nutritional quality of the food supply and provide a public health benefit with minimal risk to health.

Biofortification is the process by which the nutritional quality of food crops is improved through agronomic practices, conventional plant breeding, or modern biotechnology. Biofortification differs from conventional fortification in that biofortification aims to increase nutrient levels in crops during plant growth rather than through manual means during processing of the crops. Biofortification may therefore present a way to reach populations where supplementation and conventional fortification activities may be difficult to implement and/or limited.

Examples of biofortification projects include:

  • iron-biofortification of rice, beans, sweet potato, cassava and legumes;
  • zinc-biofortification of wheat, rice, beans, sweet potato and maize;
  • provitamin A carotenoid-biofortification of sweet potato, maize and cassava; and
  • amino acid and protein-biofortification of sourghum and cassava.

WHO Recommendations


Further research is needed before specific recommendations can be made.

Guidelines and guidance documents Learn More Alternate Text


GRC-approved guidelines


Status: Not currently available

Cost-effectiveness Learn More Alternate Text


Cost-effectiveness analyses


How Cost-Effective is Biofortification in Combating Micronutrient Malnutrition? An Ex ante Assessment

JMeenakshi JV, Johnson NL, Manyong VM, DeGroote H, Javelosa J, Yanggen DR, et al.World Development. 2010; 38(1):64-75.


Cost-Effectiveness of Golden Mustard for Treating Vitamin A Deficiency in India

Chow J, Klein EY, Laxminarayan R.PLoS One. 2010; 5(8):e12046.


Potential impact and cost-effectiveness of multi-biofortified rice in China

De Steur H, Gellynck X, Blancquaert D, Lambert W, Van Der Straeten D, Qaim M. N Biotechnol. 2012; 29(3):432-42.


Plant breeding to control zinc deficiency in India: how cost-effective is biofortification?

Stein AJ, Nestel P, Meenakshi JV, Qaim M, Sachdev HP, Bhutta ZA. Public Health Nutr. 2007; 10(5):492-501.