e-Library of Evidence for Nutrition Actions (eLENA)


An online library of evidence-informed guidelines for nutrition interventions and single point of reference for the latest nutrition guidelines, recommendations and related information.

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Vitamin D supplementation during pregnancy

Intervention | Last updated: 17 April 2023


Vitamin D is known to play an important role in bone metabolism through regulation of calcium and phosphate equilibrium. Vitamin D is produced by the body during exposure to sunlight, but is also found in oily fish, eggs and fortified food products.

Vitamin D deficiency is thought to be common among pregnant women in some populations, and has been found to be associated with an increased risk of pre-eclampsia, gestational diabetes mellitus, preterm birth, and other tissue-specific conditions.

Vitamin D supplementation during pregnancy improves maternal vitamin D status and may reduce the risk of pre-eclampsia, low birthweight and preterm birth. However, the evidence currently available to directly assess the benefits and harms of the use of vitamin D supplementation alone in pregnancy for improving maternal and infant health outcomes is limited.

Pregnant women should be encouraged to receive adequate nutrition, which is best achieved through consumption of a healthy balanced diet.

WHO Recommendations


Oral vitamin D supplementation is not recommended for all pregnant women to improve maternal and perinatal outcomes.*

* This recommendation updates and does not alter the respective WHO recommendation on vitamin D supplementation during pregnancy found in the 2016 WHO ANC guideline.



Evidence


Systematic reviews used to develop the guidelines


Vitamin D supplementation for women during pregnancy

De-Regil LM, Palacios C, Lombardo LK, Peña-Rosas JP. Cochrane Database of Systematic Reviews. 2016; Issue 1. Art. No.: CD008873.

Summary of this review Alternate Text

Related Cochrane reviews


Vitamin D supplementation for women during pregnancy.

Palacios C, Kostiuk LK, Peña‐Rosas JP. Cochrane Database of Systematic Reviews. 2019; Issue 7. Art. No.: CD008873.


Regimens of vitamin D supplementation for women during pregnancy

Palacios C, Trak‐Fellermeier MA, Martinez RX, Lopez‐Perez L, Lips P, Salisi JA, John JC, Peña‐Rosas JP. Cochrane Database of Systematic Reviews. 2019; Issue 10. Art. No.: CD013446.


Related systematic reviews


Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials

Pérez-López FR, Pasupuleti V, Mezones-Holguin E, Benites-Zapata VA, Thota P, Deshpande A, Hernandez AV. Fertility and Sterility. 2015; 103(5):1278-88.e4.


Vitamin D during pregnancy and maternal, neonatal and infant health outcomes: a systematic review and meta-analysis

Thorne-Lyman A, Fawzi WW. Paediatric and Perinatal Epidemiology. 2012; 26(s1):75–90.


Cost-effectiveness Learn More Alternate Text


Implementation of this intervention is not recommended.