e-Library of Evidence for Nutrition Actions (eLENA)


An online library of evidence-informed guidelines for nutrition interventions and single point of reference for the latest nutrition guidelines, recommendations and related information.

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Zinc supplementation in children with respiratory infections

Intervention | Last updated: 17 April 2023


Pneumonia is a severe form of acute lower respiratory tract infection and is the leading cause of death in children under 5 years of age worldwide.

Zinc is important for cellular growth, cellular differentiation and metabolism and deficiency limits childhood growth and decreases resistance to infections. Although severe zinc deficiency is rare in humans, mild to moderate deficiency may be common worldwide.

Several studies have suggested that zinc supplementation may reduce the frequency and severity of respiratory infections in children, however results thus far have been inconsistent.

WHO Recommendations


Further research is needed before specific recommendations can be made.

Guidelines and guidance documents Learn More Alternate Text


GRC-approved guidelines


Status: Not currently available

Evidence


Related Cochrane reviews


Zinc supplementation for the prevention of pneumonia in children aged 2 months to 59 months

Lassi ZS, Moin A, Bhutta ZA. Cochrane Database of Systematic Reviews. 2016; Issue 12. Art. No.: CD005978.

Summary of this review Alternate Text

Zinc supplementation for preventing mortality, morbidity, and growth failure in children aged 6 months to 12 years of age

Mayo-Wilson E, Junior JA, Imdad A, Dean S, Chan XHS, Chan ES, et al. Cochrane Database of Systematic Reviews. 2014; Issue 5. Art. No.: CD009384.

Summary of this review Alternate Text

Other related systematic reviews


Preventive zinc supplementation in developing countries: impact on mortality and morbidity due to diarrhea, pneumonia and malaria

Yakoob MY, Theodoratou E, Jabeen A, Imdad A, Eisele TP, Ferguson J, et al. BMC Public Health. 2011;11 Suppl 3:S23.


Cost-effectiveness Learn More Alternate Text


Implementation of this intervention is not recommended.