e-Library of Evidence for Nutrition Actions (eLENA)


An online library of evidence-informed guidelines for nutrition interventions and single point of reference for the latest nutrition guidelines, recommendations and related information.

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Zinc supplementation during pregnancy

Intervention | Last updated: 17 April 2023


The central role of zinc in cell division, protein synthesis and growth means that an adequate supply of zinc is especially important for pregnant women. During pregnancy, zinc and other micronutrient deficiencies are common due to increased nutrient requirements of the mother and the developing fetus. These deficiencies can negatively impact pregnancy outcomes including the health of the mother and newborn infant.

The available evidence suggests that zinc supplementation during pregnancy may help to reduce preterm births in low-income settings, but does not prevent other suboptimal pregnancy outcomes including low-birth-weight or pre-eclampsia.

WHO Recommendations


Zinc supplementation for pregnant women is only recommended in the context of rigorous research.

Evidence


Systematic reviews used to develop the guidelines


Zinc supplementation for improving pregnancy and infant outcome

Ota E, Mori R, Middleton P, Tobe-Gai R, Mahomed K, Miyazaki C, Bhutta ZA. Cochrane Database of Systematic Reviews. 2015; Issue 2. Art. No.: CD000230.

Summary of this review Alternate Text

Related systematic reviews


Effect of Zinc Supplementation on Pregnancy and Infant Outcomes: A Systematic Review

Chaffee BW, King JC. Paediatric and Perinatal Epidemiology. 2012; 26(s1):118–137.


A systematic review of effect of prenatal zinc supplementation on birthweight: meta-analysis of 17 randomized controlled trials

Gebreselassie SG, Gashe FE. Journal of Health, Population and Nutrition. 2011; 29(2).


Cost-effectiveness Learn More Alternate Text


Implementation of this intervention is not recommended.