e-Library of Evidence for Nutrition Actions (eLENA)


An online library of evidence-informed guidelines for nutrition interventions and single point of reference for the latest nutrition guidelines, recommendations and related information.

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Zinc supplementation and growth in children

Intervention | Last updated: 17 April 2023


Approximately 155 million children under five years of age are stunted (height-for-age <-2 SD below the WHO Child Growth Standards median), with the vast majority living in Africa and Asia.

Zinc is important for cellular growth, cellular differentiation and metabolism and deficiency limits childhood growth and decreases resistance to infections. Although severe zinc deficiency is rare in humans, mild to moderate deficiency may be common worldwide.

The available evidence is inconsistent, but suggests that zinc supplementation may help to improve linear growth of children under 5 years of age.

WHO Recommendations


Further research is needed before specific recommendations can be made.

Guidelines and guidance documents Learn More Alternate Text


GRC-approved guidelines


Status: Not currently available

Evidence


Related Cochrane reviews


Zinc supplementation for preventing mortality, morbidity, and growth failure in children aged 6 months to 12 years of age

Mayo-Wilson E, Junior JA, Imdad A, Dean S, Chan XHS, Chan ES, et al. Cochrane Database of Systematic Reviews. 2014; Issue 5. Art. No.: CD009384.

Summary of this review Alternate Text

Other related systematic reviews


Effect of preventive zinc supplementation on linear growth in children under 5 years of age in developing countries: a meta-analysis of studies for input to the lives saved tool

Imdad A, Bhutta ZA. BMC Public Health. 2011; 11(Suppl. 3):S22.


Preventive zinc supplementation among infants, preschoolers, and older prepubertal children

Brown KH, Peerson JM, Baker SK, Hess SY. Food & Nutrition Bulletin. 2009; 30(Suppl. 1):S12-40.


Effects of micronutrients on growth of children under 5 y of age: meta-analyses of single and multiple nutrient interventions

Ramakrishnan U, Nguyen P, Martorell R. American Journal of Clinical Nutrition. 2009; 89(1):191–203.


Cost-effectiveness Learn More Alternate Text


Relevant cost-effectiveness analyses have not yet been identified.