Control of Neglected Tropical Diseases
We coordinate and support policies and strategies to enhance global access to interventions for the prevention, control, elimination and eradication of neglected tropical diseases, including some zoonotic diseases.

Preventive chemotherapy

Preventive chemotherapy is the large-scale delivery of safe, single-administration, quality-assured medicines, either alone or in combination, at regular intervals, to entire population groups.

WHO recommends preventive chemotherapy as the core strategic intervention against four main helminth diseases: lymphatic filariasis, onchocerciasis, schistosomiasis and soil-transmitted helminthiases. Preventive chemotherapy is also a component of the SAFE (Surgery, Antibiotics, Facial cleanliness and Environmental improvements) strategy for the control, prevention and elimination of trachoma. It is recommended also for controlling morbidity due to foodborne trematode infections, and is a strategic component of WHO-recommended strategies against leprosy, scabies, taeniasis and yaws.

Medicines are generally delivered and administered to entire eligible populations or population groups mostly by non-medical personnel following a short training session. Schools, community networks and other social platforms are extensively used as outreach points to maximize coverage.

Preventive chemotherapy is implemented along with complementary public health interventions, such as management of chronic cases and people with disabilities, control of vectors and their intermediate hosts, veterinary public health services, and access to safe drinking-water, sanitation and hygiene services. Such measures enhance the impact of the intervention both in terms of controlling morbidity and in decreasing transmission.
Implementation of preventive chemotherapy interventions is made possible thanks to large-scale donations of medicines by the pharmaceutical industry, either through WHO or directly to countries, and to availability of funding for scaling up, through sustained commitment of international donors and enhanced in-country support by the health and education sectors. Between 2015 and 2019, and thanks to additional and increased medicine donations, more than one billion people were treated annually through preventive chemotherapy for at least one of the five diseases amenable to the intervention.

 

 

Fighting Trachoma in Mozambique2
RTI International/Damien Schumann
A child receives the proper dosage of Zithromax during a treatment campaign for trachoma in Mozambique.
© Credits

Resources

Key publication

Standard operating procedures for supply chain management of health products for neglected tropical diseases amenable to preventive chemotherapy
WHO plays a major role in the cycle of supply chain management for donated and/or procured health products for neglected tropical diseases (NTDs) amenable...
Crossing the Billion. Preventive chemotherapy for neglected tropical diseases
Lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiases and trachoma
Preventive chemotherapy: tools for improving the quality of reported data and information: a field manual for implementation
Preventive chemotherapy is one of the main interventions used by national programmes to control and eliminate five neglected tropical diseases (NTDs):...
Monitoring drug coverage for preventive chemotherapy – Manual
Preventive anthelminthic chemotherapy aims at using available anthelminthic drugs either alone or in combination as a public health tool for preventing...

Latest publications

All →
Global update on implementation of preventive chemotherapy against neglected tropical diseases (‎NTDs)‎ in 2023 and status of donated medicines for NTDs in 2024

Summary of preventive chemotherapy (PC) in 2023 PC is defined as large-scale delivery of safe, single-administration, quality-assured medicines, either...

Schistosomiasis and soil-transmitted helminthiases: progress report, 2023

Human infection with schistosomes and soil-transmitted helminths is the cause of clinical morbidity in many areas of the world. Human schistosomiasis...

Global programme to 
eliminate lymphatic 
filariasis: progress report, 
2023

Lymphatic filariasis (LF) is a vector-borne disease in humans caused by infection with the filarial parasites Wuchereria bancrofti, Brugia malayi and...

Tools

A health worker in South Sumatra records and reviews information during a mass drug administration for the elimination of lymphatic filariasis in South Sumatra.

WHO facilitates the supply of some medicines donated by the pharmaceutical industry. A joint mechanism and a set of forms have been developed to facilitate the process of application, review and reporting as well as to improve coordination and integration among different programmes.

33689702001_5b6a50e93f_o

Progress towards achieving the Roadmap targets for control and elimination of the Neglected Tropical Diseases

Fighting LF in Indonesia, 2018

This platform allows access to interactive report on status of distribution and implementation for lymphatic filariasis, onchocerciasis, soil-transmitted helminthiases, schistosomiasis and trachoma

Ademocha and Aidika administer medicine to prevent and treat lymphatic filariasis in Cross River State, Nigeria.

Dose poles (height based) used to assess recommended doses of praziquantel and ivermectin to be given to individual person during mass-drug administration.

Disease specific request forms for selected PC medicines

Foodborne trematode infections

Related activities